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In situ" refers to the fact that the cancer hasn't spread beyond its point of origin. In this case, the disease is confined to the milk ducts and has not invaded nearby breast tissue. If untreated, ductal carcinoma in situ may become invasive cancer. It is often curable. Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Tamoxifen Nolvadex is used to help treat and prevent these types of cancer. Anise seems to also affect estrogen levels in the body. By affecting estrogen in the body, anise might decrease the effectiveness of tamoxifen Nolvadex. Do not take anise if you are taking tamoxifen Nolvadex.

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Gehri, M. Severe methemoglobinemia due to food intoxication in infants. Pediatr. Turner RT, Wakley GK, Hannon KS et al. Tamoxifen prevents the skeletal effects of ovarian hormone deficiency in rats. J Bone Miner Res. Gescher, A. Effect of quercetin on the genotoxic potential of cisplatin. Rhyu, M. R. Extracts from Schizandra chinensis fruit activate estrogen receptors: a possible clue to its effects on nitric oxide-mediated vasorelaxation. Biol Pharm.

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Cuenca RE, Giachino J, Arrendondo MA, Hempling R, Edge SB "Endometrial carcinoma associated with breast carcinoma: low incidence with tamoxifen use. Sanz, J. Comparison of the volatile composition of wild fennel samples Foeniculum vulgare Mill. Keep XELODA in a tightly closed container.

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Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Yan, Y, Cheng Dong, and Yao WenHuan. Experimental study on the effects of Rhodiola Sachalinensis and Acanthopanax Senticosus extracts on the hypoxia tolerance of mice. Nolvadex is a nonsteroidal agent that has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene DMBA and causes the regression of already established DMBA-induced tumors. In this rat model, tamoxifen appears to exert its antitumor effects by binding the estrogen receptors.

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AstraZeneca Pharmaceuticals. Nolvadex tamoxifen citrate prescribing information. Wilmington, DE; 2003 Jun. Silk vine is a common adulterant of Siberian ginseng. The second trial, the Royal Marsden Trial RMT was reported as an interim analysis. The RMT was begun in 1986 as a feasibility study of whether larger scale trials could be mounted. The trial was subsequently extended to a pilot trial to accrue additional participants to further assess the safety of tamoxifen. Twenty-four hundred and seventy-one women were entered between 1986 and 1996; they were selected on the basis of a family history of breast cancer. HRT was used in 40% of participants. In this trial, with a 70 month median follow-up, 34 and 36 breast cancers 8 noninvasive, 4 on each arm were observed among women on tamoxifen and placebo, respectively. Patients in this trial were younger than those in the NSABP P-1 trial and may have been more likely to develop ER - tumors, which are unlikely to be reduced in number by tamoxifen therapy. Although women were selected on the basis of family history and were thought to have a high risk of breast cancer, few events occurred, reducing the statistical power of the study. These factors are potential reasons why the RMT may not have provided an adequate assessment of the effectiveness of tamoxifen in reducing the incidence of breast cancer. LV vs XELODA difference. Fisher B, Redmond C, Brown A et al. Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial. J Clin Oncol. Amaryan G, Astvatsatryan V, Gabrielyan E, et al. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Laakmann G, Schule C, Baghai T, Kieser M. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. The chemicals in schisandra improve liver function by stimulating enzymes proteins that speed up biochemical reactions in the liver and promoting liver cell growth. Mukerji, K. G. Improved growth and essential oil yield and quality in Foeniculum vulgare mill on mycorrhizal inoculation supplemented with P-fertilizer. Bioresour. Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. Siberian ginseng is a plant. People use the root of the plant to make medicine. Siberian ginseng is often called an “adaptogen. No deformations were seen and, although the dose was high enough to terminate pregnancy in some animals, those that did maintain pregnancy showed no evidence of teratogenic malformations. In these trials, an increased number of cases of deep vein thrombosis, pulmonary embolus, stroke, and endometrial cancer were observed on the tamoxifen arm compared to the placebo arm. The frequency of events was consistent with the safety data observed in the NSABP P-1 trial.

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That means the cells grow in response to the hormone estrogen. About 65% of these are also “PR-positive. Always take Tamoxifen exactly as your doctor has told you. MS and 1H-NMR methods. Phytochem. Dengler, H. J. Disposition of quercetin in man after single oral and intravenous doses. Eur. Tesar, V. The effect of silibinin on experimental cyclosporine nephrotoxicity. Ren Fail. Do not eat or drink anything other than plain water. Medroxyprogesterone reduces plasma concentrations of N-desmethyl tamoxifen metabolite but not tamoxifen. Caucasian patients. The clinical significance of these differences is unknown. CLOMID, at recommended dosages, is generally well tolerated. If you are taking tamoxifen to reduce the risk of breast cancer, or if your cancer is limited to the milk ducts ductal carcinoma in situ-DCIS then discuss the benefits and risks of taking this medication with your doctor. However, if you are taking tamoxifen to treat breast cancer, then the benefits of taking tamoxifen are greater than the risks of side effects. Anastrozole which is used to treat breast cancer. Twenty-eight female pediatric patients, aged 2 to 10 years, were treated for up to 12 months. Effect of treatment on frequency of vaginal bleeding, bone age advancement, and linear growth rate was assessed relative to prestudy baseline. Bomser J, Madhavi DL, Singletary K, Smith MA. In vitro anticancer activity of fruit extracts from Vaccinium species. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Since this drug can be absorbed through the and and may harm an unborn baby, women who are or who may become pregnant should not handle this medication or breathe the dust from the tablets. nimodipine

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Changes in vision due to cataracts or changes to the retina of your eye. Ben-Shlomo I, Zohar S "Quadruplets following cessation of clomiphene citrate. A case of sustained effect. Ko, K. M. Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radic. Neven P, De Muylder X, Van Belle Y et al. Tamoxifen and the uterus and endometrium. Lancet. Eyes: Changes to your vision and difficulty seeing. Panossian, A. and Wikman, G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. National Cancer Institute NCI. NCI issues clinical announcement about long-term use of tamoxifen in breast cancer treatment. Bethesda, MD. 1995 Nov 30. Press release. Some people using medicines similar to Reclast have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia low red blood cells and pre-existing dental problems. phenazopyridine

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Reddy, M. V. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice. One study has reported that when compared to healthy controls who were not using the drug, tamoxifen the active ingredient contained in Nolvadex users exhibited significantly worse performance on visual memory, word fluency, immediate verbal memory, visuo-spatial ability, and processing speed tasks. Nervous system: Headaches, feeling light-headed. Alcohol can cause sleepiness and drowsiness. Siberian ginseng might also cause sleepiness and drowsiness. Taking large amounts of Siberian ginseng along with alcohol might cause too much sleepiness. These drugs trigger the growth of eggs in your ovaries. Hendrich, S. and Bjeldanes, L. F. Effects of dietary Schizandra chinensis, brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver. Food Chem. Nasiri, A. Antihirsutism activity of Fennel fruits of Foeniculum vulgare extract. A double-blind placebo controlled study. Phytomedicine. Do not have blood drawn from the arm on the side of the lymph node surgery. Tamoxifen concentrations may be increased. An addition, bromocriptine GI adverse reactions eg, abdominal pain may be increased. Avoid coadministration if serious bromocriptine adverse reactions occur. Inherited fever disorder . Early research suggests that taking a combination product ImmunoGuara, Inspired Nutritionals containing andrographis, Siberian ginseng, schisandra, and licorice reduces the severity and frequency of familial Mediterranean fever attacks. Gozu, Y. Effects of fragrance inhalation on sympathetic activity in normal adults. Jpn. SOGC Clinical Practice Guideline. Recurrent urinary tract infection. If ovulation does not appear to occur after the first course of therapy, a second course of 100 mg daily two 50 mg tablets given as a single daily dose for 5 days should be given. This course may be started as early as 30 days after the previous one after precautions are taken to exclude the presence of pregnancy. Nortriptyline Pamelor is a tricyclic antidepressant. The body breaks down nortriptyline Pamelor to get rid of it. St. John's wort can increase how quickly the body breaks down nortriptyline Pamelor. This could decrease the effectiveness of nortriptyline Pamelor. Harkins K. What's the use of cranberry juice? buy cheapest probenecid store usa

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Sandstrom, B. Effect of diets based on foods from conventional versus organic production on intake and excretion of flavonoids and markers of antioxidative defense in humans. The benefits of Nolvadex outweigh its risks in women already diagnosed with breast cancer. Sui, D. Acanthopanax senticosides B ameliorates oxidative damage induced by hydrogen peroxide in cultured neonatal rat cardiomyocytes. Eur J Pharmacol. Killackey MA, Hakes TB, Pierce VK. Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens. Cancer Treat Rep. Common cold. Early research suggests that inhaling a German chamomile product Kneipp-Kamillen-Konzentrat as steam with hot water for 10 minutes reduces common cold symptoms. Pneumonia. Early research suggests that taking a combination of rhodiola, schisandra, and Siberian ginseng Chisan along with standard treatment for 10-15 days helps reduce the length of time that antibiotics are needed and may improve quality of life in people with pneumonia better than standard treatment alone. Long-term effects not established. Singh, A. K. Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. More evidence is needed to rate cranberry for these uses. Sawka CA, Pritchard KI, Paterson AH et al. Role and mechanism of action of tamoxifen in premenopausal women with metastatic breast carcinoma. Cancer Res. Tong, E. Experimental study on the protective effect of puerarin to Parkinson disease. J Huazhong.

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Baranov, A. I. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Twenty-five percent of the participants received drug for 5 years. The longer-term effects are not known. In this study, there was no impact of tamoxifen on overall or breast cancer-related mortality see at the beginning of the label. Ko, K. M. Effect of schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity. If you miss a dose of anastrozole, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. It can also be used for early-stage breast cancer. But there is a small but real risk of damage and possible damage. Scientists are still studying how long women should take this for the greatest benefit. KANEKO, K. Biogenetic studies of natural products. VIII. Biosynthesis of anethole by Foeniculum vulgare. 4. Chem. Medon PJ, Ferguson PW, Watson CF. Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro. Sometimes, you may need to get injections along with Clomid that you take by mouth. This medication may interfere with certain laboratory tests including thyroid tests possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Evaluate renal function prior to administration and periodically during treatment. For patients with compromised renal function, monitor for toxicity more frequently. Asghar, Z. and Masood, Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak. cheapest pharmacy for baclofen

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It is not known whether letrozole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using letrozole. Kim, J. K. Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice. Int Immunopharmacol. Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study. J Spinal Cord. Some of the strokes, pulmonary emboli, and uterine malignancies were fatal. Odunola, O. A. Comparative effects of some local food condiments on sodium arsenite-induced clastogenicity. Afr. is it ok to euthyrox

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Some of these medications that are changed by the liver include clozapine Clozaril cyclobenzaprine Flexeril fluvoxamine Luvox haloperidol Haldol imipramine Tofranil mexiletine Mexitil olanzapine Zyprexa pentazocine Talwin propranolol Inderal tacrine Cognex theophylline, zileuton Zyflo zolmitriptan Zomig and others. The risk for developing breast cancer increases as a woman ages. Yoo, K. P. Effect of plant matrix and fluid ethanol concentration on supercritical fluid extraction efficiency of schisandrin derivatives. J Chromatogr. Pritchard KI, Thomson DB, Myers RE et al. Tamoxifen therapy in premenopausal patients with metastatic breast cancer. Cancer Treat Rep. Life-threatening hypercalcemia may occur during initial therapy with tamoxifen in patients with bone metastases. Monitoring of serum calcium levels during early therapy is recommended for patients in whom bone metastases are present or are suspected. In cases of severe hypercalcemia, discontinuation of tamoxifen may be warranted, with reinstitution at a lower dose once calcium levels have normalized. Ostad SN, Soodi M, Shariffzadeh M, et al. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. It can also spread to other areas in the body. How is invasive lobular carcinoma diagnosed? venlafaxine

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Tamoxifen is used to treat breast cancer that has spread to other parts of the body metastatic breast cancer to treat breast cancer in certain patients after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients. You should not use this medication if you are allergic to letrozole, or if you have not gone completely through menopause. Zhu W, Zhang JS, Young CY. Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol. Mira ML, Azevedo MS, and Manso C. The neutralization of hydroxyl radical by silibin, sorbinil and bendazac. Formica, J. V. and Regelson, W. Review of the biology of Quercetin and related bioflavonoids. Food Chem. XELODA can cause serious skin reactions that may lead to death. Yalcinkaya, B. Repellent activity of five essential oils against Culex pipiens. Charousaei F, Dabirian A, Mojab F. Using chamomile solution or a 1% topical hydrocortisone ointment in the management of peristomal skin lesions in colostomy patients: results of a controlled clinical study. Symptoms of a stroke. Kennedy, D. A. Posttraining D1 receptor blockade impairs odor conditioning in neonatal rats. Behav. Aviram, M. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler. Qin, L. P. Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus. J Ethnopharmacol. The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. Murota, K. Vegetable flavonoids and cardiovascular disease. Asia Pac.

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Hankinson SE, Willett WC, Colditz GA et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. Lean, M. E. Prediction of dietary flavonol consumption from fasting plasma concentration or urinary excretion. Srinivasan, K. In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine. Mephenytoin Mesantoin is changed and broken down by the body. St. John's wort increases how quickly this medication is broken down by the body. This might decrease the effectiveness of mephenytoin Mesantoin. Stop taking this medication and tell your doctor right away if this very serious side effect occurs: lactic acidosis see Warning section. Liu, X. W. Anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus. Molecules. Aro, A. Tea and coronary heart disease: the flavonoid quercetin is more bioavailable from rutin in women than in men. Arch. tretinoin order pharmacy europe

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Fennel might relax the and decrease respiratory tract secretions. Jaiyesimi IA, Buzdar AU, Sahin AA et al. Carcinoma of the male breast. Ann Intern Med. Some medications changed by the liver include lovastatin Mevacor ketoconazole Nizoral itraconazole Sporanox fexofenadine Allegra triazolam Halcion and many others. Ltd, Station Close, Potters Bar, Herts, EN6 1TL. Fennel powder is used as a poultice for snakebites. In foods and beverages, fennel oil is used as a flavoring agent. Nolvadex may reduce the number of clot-forming cells platelets in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools. Anon. Tamoxifen for node-negative breast cancer. FDA Drug Bull. You may start treatment with Tamoxifen on any day. Some medications are changed and broken down by the liver. St. John's wort might increase how quickly the liver breaks down some medications. Taking St. John's wort along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking St. John's wort, talk to your healthcare provider if you take any medications that are changed by the liver. Dhar, S. K. Anti-fertility activity and hormonal profile of trans-anethole in rats. Lucio-Gutiérrez, J. R, Coello, J, and Maspoch, S. Application of near infrared spectral fingerprinting and pattern recognition techniques for fast identification of Eleutherococcus senticosus. McNaughton, L. G. Egan and G. Caelli. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. betamethasone

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Andersen, K. E. Contact allergy to toothpaste flavors. Millions of women have taken tamoxifen during the last 30 years, but the risks and benefits of the drug have long been debated. Instead, the doctor may recommend keeping a close eye on your condition. That means regular breast self-exams, office visits, and routine mammograms or other tests such as MRIs. Moderate Be cautious with this combination. Claude, J. R. Study of glutathione and glutathione related enzymes in acetaminophen-poisoned mice. Prevention by anethole trithione pretreatment. Arch Toxicol.

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Nolvadex may be taken by mouth with or without food. These metabolites cause cell injury by two different mechanisms. Wear comfortable and supportive shoes that fit properly. Lapenna, S. and Dinan, L. HPLC and TLC characterisation of ecdysteroid alkyl ethers. J Chromatogr. Martinez, B. and Staba, E. J. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats.

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Fugh-Berman, A. Herbal Supplements: Indications, Clinical Concerns, and Safety. Symptoms of alcohol hangover headache, upset stomach, dizziness and vomiting. Your doctor will also take samples from your lymph nodes in the armpits to check for cancer. This is called axillary lymph node dissection. Wiseman, H. Effect of dietary quercetin on oxidative DNA damage in healthy human subjects. Vita, J. A. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease.

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Jaiyesimi IA, Buzdar AU, Decker DA, Hortobagyi GN "Use of tamoxifen for breast cancer: twenty-eight years later. Creamer P, Lim K, George E, Dieppe P "Acute inflammatory polyarthritis in association with tamoxifen. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Ikeya, Y. Antihepatotoxic actions of lignoids from Schizandra chinensis fruits.

Smith, M. and Boon, H. S. Counseling cancer patients about herbal medicine. Patient. IV bolus 5-FU, on days 1-5, every 28 days. Tamoxifen is extensively metabolized after oral administration. N-desmethyl tamoxifen is the major metabolite found in patients' plasma. The biological activity of N-desmethyl tamoxifen appears to be similar to that of tamoxifen. 4-Hydroxytamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma. Tamoxifen is a substrate of cytochrome P-450 3A, 2C9 and 2D6, and an inhibitor of P-glycoprotein. Pinto HC, Baptista A, Camilo ME, Decosta EB, Valente A, Demoura MC "Tamoxifen-associated steatohepatitis - report of three cases.

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